Safety
WARNING: FETAL TOXICITY

The safety of the maximum dose of PRESTALIA 14/10 mg was evaluated in a 6-week clinical trial of 279 patients with hypertension and compared with perindopril erbumine 16 mg and amlodipine 10 mg. Adverse reactions were generally mild and transient in nature.1

Adverse events
The safety of the maximum dose of PRESTALIA 14/10 mg was evaluated in a 6-week clinical trial of 279 patients with hypertension and compared with perindopril erbumine 16 mg and amlodipine 10 mg. Adverse reactions were generally mild and transient in nature.1
Adverse Event PRESTALIA
14/10 mg
(N = 279) / n (%)
perindopril erbumine
16 mg
(N = 278) / n (%)
amlodipine
10 mg
(N = 280) / n (%)
Edema peripheral 20 / (7.2) 1 / (0.4) 37 / (13.2)
Cough 9 / (3.2) 8 / (2.9) 2 / (0.7)
Headache 7 / (2.5) 8 / (2.9) 8 / (2.9)
Dizziness 7 / (2.5) 4 / (1.4) 3 / (1.1)

PRESTALIA is available as white, uncoated tablets containing perindopril arginine 3.5 mg, 7 mg, or 14 mg and amlodipine 2.5 mg, 5 mg, or 10 mg for the following 3 combinations of perindopril arginine /amlodipine: 3.5/2.5 mg, 7/5 mg, 14/10 mg. All 3 strengths are packaged in bottles of 90 tablets. Each tablet is debossed with tablet strength.1

PRESTALIA IS AVAILABLE THROUGH bpCareConnect, A HYPERTENSION MANAGEMENT PROGRAM FROM SYMPLMED.
References: 
  1. PRESTALIA [package insert]. Cincinnati, OH: Symplmed, LLC; 2015.
  2. Bangalore S, Kamalakkannan G, Parkar S, Messerli, FH. Fixed-dose combinations improve medication compliance: A meta-analysis. Am J Med.:2007; 120(8) 713-719.